Sources and evolution of human Alu repeated sequences.

AUTOR(ES)

Britten, R J

RESUMO

Alu repeated sequences arising in DNA of the human lineage during about the last 30 million years are closely similar to a modern consensus. Alu repeats arising at earlier times share correlated blocks of differences from the current consensus at diagnostic positions in the sequence. Using these 26 positions, we can recognize four subfamilies and the older ones are each successively closer to the 7SL sequence. It appears that there has existed a series of conserved genes that are the primary sources of the Alu repeat family, presumably through retroposition. These genes have probably replaced each other in overlapping relays during the evolution of primates.

Documentos Relacionados

• A fundamental division in the Alu family of repeated sequences.
• Species-specific homogeneity of the primate Alu family of repeated DNA sequences.
• Molecular evolution of the human adult alpha-globin-like gene region: insertion and deletion of Alu family repeats and non-Alu DNA sequences.
• Transcriptional measurements of mouse repeated DNA sequences.
• Polymorphism and evolution of Alu sequences in the human low density lipoprotein receptor gene.