Spatial parasite transmission, drug resistance, and the spread of rare genes
AUTOR(ES)
Cornell, S. J.
FONTE
National Academy of Sciences
RESUMO
The transmission of many parasitic worms involves aggregated movement between hosts of “packets” of infectious larvae. We use a generic metapopulation model to show that this aggregation naturally promotes the preferential spread of rare recessive genes, compared with the expectations of traditional nonspatial models. A more biologically realistic model also demonstrates that this effect could explain the rapid observed spread of recessive or weakly dominant drug-resistant genotypes in nematode parasites of sheep. This promotion of a recessive trait arises from a novel mechanism of inbreeding arising from the metapopulation dynamics of transmission.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=165887Documentos Relacionados
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