Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus.
AUTOR(ES)
Stober-Grässer, U
RESUMO
The protein product of the v-myb oncogene of avian myeloblastosis virus, p48v-myb, differs structurally in several ways from its normal cellular homolog, p75c-myb. We demonstrated that the 11 specific amino acid substitutions found in two independent molecular clones of this virus were not required for the transformation of myeloblasts by v-myb.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=253675Documentos Relacionados
- Transformation of myelomonocytic cells by the avian myeloblastosis virus is determined by the v-myb oncogene, not by the unique long terminal repeats of the virus.
- Transformation of chicken myelomonocytic cells by a retrovirus expressing the v-myb oncogene from the long terminal repeats of avian myeloblastosis virus but not Rous sarcoma virus.
- env-encoded residues are not required for transformation by p48v-myb.
- v-myb does not prevent the expression of c-myb in avian erythroblasts.
- Transformation by v-myb correlates with trans-activation of gene expression.
