Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia.
AUTOR(ES)
Leib, D A
RESUMO
Two specific inhibitors of herpes simplex virus thymidine kinase, N2-phenyl-2'-deoxyguanosine and N2-(m-trifluoromethylphenyl)guanine, were tested for their ability to inhibit the reactivation of virus from explant cultures of latently infected murine trigeminal ganglia. Both compounds significantly diminished the frequency of reactivation compared with that of untreated controls.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=171804Documentos Relacionados
- Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia.
- Secondary herpes simplex virus latent infection in transplanted ganglia.
- Latent infections in spinal ganglia with thymidine kinase-deficient herpes simplex virus.
- Latent herpes simplex virus type 1 transcription in human trigeminal ganglia.
- Limited transcription of the herpes simplex virus genome when latent in human sensory ganglia.