SPECTROSCOPIC STUDY OF ALUMINUM PHTHALOCYANINE CHLORIDE (AlPcCl) IN HOMOGENEOUS AND MICRO-HETEROGENEOUS MEDIA CONSISTING OF P-123 AND F-127 POLYMERIC MICELLES
AUTOR(ES)
Vilsinski, Bruno H., Gerola, Adriana P., Lemos, Évelin O., Barbosa, Patrícia M., Campanholi, Katieli S. S., César, Gabriel B., Hioka, Noboru, Caetano, Wilker
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2015-06
RESUMO
Aluminum phthalocyanine chloride (AlPcCl) is a photoactive compound which has been used as a photosensitizer (PS) in photodynamic therapy (PDT). Its spectroscopic properties have been studied in solvents of different polarities (ethanol, acetone, dimethylsulfoxide and chloroform). Its solubility has been found to decrease with increasing solvent polarity, together with full self-aggregation in aqueous solution. The binding of AlPcCl to the copolymer PluronicTM micellar class P-123 and F-127 used as solubilizer/carriers was studied. Greater interaction between the more hydrophobic copolymer P-123 and AlPcCl was observed, besides a complex interaction profile involving different AlPcCl forms (self-aggregate/monomeric form) in the copolymers. Time- and temperature-dependent structural organization of AlPcCl in the copolymers was also observed. Thus, AlPcCl has a strong tendency to self-aggregate with increasing solvent polarity, an effect also observed in micellar media.
Documentos Relacionados
- Physico-chemical properties of meso-tetrakis(p-methoxyphenyl)porphyrin (TMPP) incorporated into pluronicTM p-123 and f-127 polymeric micelles
- Assessment of Leishmania major and Leishmania braziliensis promastigote viability after photodynamic treatment with aluminum phthalocyanine tetrasulfonate (AlPcS4)
- Binary mixture micellar systems of F127 and P123 for griseofulvin solubilisation
- BINARY MICELLES (E45S8/F127) FOR QUERCETIN AND GRISEOFULVIN SOLUBILISATION
- Synergistic Effect in Drug Solubility by New Binary Micelles of Poly(ε-caprolactone)-poly(ethylene oxide) and F127®