Spontaneous Allozyme Mutations in DROSOPHILA MELANOGASTER: Rate of Occurrence and Nature of the Mutants
AUTOR(ES)
Voelker, Robert A.
RESUMO
After additional generations of accumulation of allozyme mutants, the 1,000 lines of Mukai and Cockerham (1977) were again screened for the same five loci (α-Gpdh, cMdh, Adh, Hex-C and α-Amy), as well as for two new loci (Got-2 and Dip-A). Based on 3,111,598 allele generations: (1) the average mutation rate to new mobility variants with normal function was estimated to be 1.28 x 10-6, and (2) the average mutation rate to null alleles was estimated to be 3.86 x 10-6. A qualitative analysis of the nulls provided evidence that most of the mutants recovered are due to base substitutions. No apparent correlation was observed between structural gene size and mutation rate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1214193Documentos Relacionados
- The Beadex Locus in Drosophila Melanogaster: On the Nature of the Mutants Bxr and Bx1
- Superoxide dismutase in Drosophila melanogaster: biochemical and structural characterization of allozyme variants.
- The nature of unstable insertion mutations and reversions in the locus cut of Drosophila melanogaster: molecular mechanism of transposition memory
- Hybrid Dysgenesis in DROSOPHILA MELANOGASTER: Nature and Inheritance of P Element Regulation
- The Genetics of Catalase in Drosophila Melanogaster: Isolation and Characterization of Acatalasemic Mutants