Spontaneous and egg antigen-induced syntheses of immunoglobulin and antibody by spleen cells and hepatic granulomas of mice infected with Schistosoma japonicum.
AUTOR(ES)
Stavitsky, A B
RESUMO
In the absence of egg antigen (SEA), spleen cells from C57BL/6 mice infected for 22 weeks with Schistosoma japonicum were spontaneously induced in vitro to synthesize total immunoglobulin and antibody to SEA. Hepatic granulomas from mice infected for 12 weeks, but not for 22 weeks, also showed spontaneous syntheses of total immunoglobulin and antibody to SEA, but these syntheses were not enhanced upon the addition of SEA. Total immunoglobulin production was enhanced when SEA was added to spleen cells from mice infected for 4 to 7 weeks but not at any other time point.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=261476Documentos Relacionados
- Deficiency of interleukin-2 production upon addition of soluble egg antigen to cultures of isolated hepatic granulomas or hepatic granuloma cells from mice infected with Schistosoma japonicum.
- Deficiency of interleukin-2 activity upon addition of soluble egg antigen to cultures of spleen cells from mice infected with Schistosoma japonicum.
- Regulation of egg antigen-induced in vitro proliferative response by splenic suppressor T cells in murine Schistosoma japonicum infection.
- Thymocytotoxic autoantibodies found in mice infected with Schistosoma japonicum.
- Mechanism of antigen-induced antibody biosynthesis from antibody precursors, the heavy and light immunoglobulin chains