Stable growth transformation of human T lymphocytes by herpesvirus saimiri.
AUTOR(ES)
Biesinger, B
RESUMO
Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and in rabbits, and it is able to immortalize monkey T lymphocytes in vitro. Sequences responsible for these effects have been localized to a region of the genome that varies significantly among the virus subgroups A, B, and C. We now report that infection of human blood lymphocytes and thymocytes with strains of subgroup C, in contrast to viruses of the other subgroups, yields continuously proliferating T-cell lines with the phenotype of mature CD4- or CD8-positive cells. Infection with strains of Herpes-virus saimiri subgroup C can thus be used to generate human T-cell lines for a variety of immunological and developmental studies.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=48815Documentos Relacionados
- Transformation of owl monkey T cells in vitro with Herpesvirus saimiri.
- Immortalization of human T cells expressing T-cell receptor gamma delta by herpesvirus saimiri.
- Herpesvirus saimiri.
- Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector.
- Structural proteins of Herpesvirus saimiri.
