Stereochemical basis of DNA bending by transcription factors.
AUTOR(ES)
Suzuki, M
RESUMO
Superstructure-formation of DNA plays an important role in transcription regulation as well as in chromatin formation. To understand the stereochemical basis of DNA bending by proteins we analysed the structural characteristics of dinucleotide steps which occur at the site where DNA is bent upon binding a transcription factor. When DNA is considerably bent in a crystal structure the bending is not spread smoothly over a length, but the DNA is kinked at a pair of crucial steps which are highly rolled and untwisted. These rolled steps are spaced 6-10 bp apart and are predominantly occupied by pyrimidine-purine sequences. In association with another dinucleotide step at the centre, which combines 6 bp-spaced rolled steps towards the same side of the DNA, these produce two essentially different types of DNA bending.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=306994Documentos Relacionados
- Stereochemical basis of DNA recognition by Zn fingers.
- Solution structure of the MEF2A–DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors
- DNA-binding specificity of GATA family transcription factors.
- Control of HPV 18 DNA replication by cellular and viral transcription factors.
- DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bending.
