Stimulation of Bordetella pertussis Adenylate Cyclase Toxin Intoxication by Its Hemolysin Domain

AUTOR(ES)

Iwaki, Masaaki

FONTE

American Society for Microbiology

RESUMO

The internalization of the N-terminal catalytic domain of Bordetella pertussis adenylate cyclase toxin (ACT) across the cytoplasmic membrane has been considered to occur independently from protein-protein interactions which can lead to oligomerization required for hemolytic activity by its C-terminal hemolysin domain. Here we report that when added in excess, this hemolysin domain stimulates the internalization, suggesting the involvement of protein-protein interactions in cell-invasive activity of ACT, as well as its hemolytic activity.

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