Stochastic theory of ligand migration in biomolecules.

AUTOR(ES)

Alberding, N

RESUMO

When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 10(3) bars (0.1 to 100 MPa) is treated.

Documentos Relacionados

• Spin-labeled biomolecules.
• High-resolution tandem mass spectrometry of large biomolecules.
• Signaling by nonreceptor surface-mediated redox-active biomolecules.
• Photocleavable biotin derivatives: a versatile approach for the isolation of biomolecules.
• Colloidal gold particles as an incompressible atomic force microscope imaging standard for assessing the compressibility of biomolecules.