Strategies by which some pathogenic trichomonads integrate diverse signals in the decision-making process

AUTOR(ES)

LÓPEZ, LUCIENE BOTTENTUIT, BRAGA, MARIANE BANDEIRA DE MELO, ORTEGA LÓPEZ, JAIME, ARROYO, ROSSANA, SILVA FILHO, FERNANDO COSTA E

FONTE

Anais da Academia Brasileira de Ciências

DATA DE PUBLICAÇÃO

2000-06

RESUMO

The interaction between each one of Trichomonas vaginalis and Tritrichomonas foetus with their hosts is a complex process in which components associated to the cell surfaces of both parasites and host epithelial cells, and also to soluble components found in vaginal/urethral secretions, are involved. Either cytoadhesion or the cytotoxicity exerted by parasites to host cells can be dictated by virulence factors such as adhesins, cysteine proteinases, laminin-binding proteins, integrins, integrin-like molecules, a cell detachment factor, a pore-forming protein, and glycosidases among others. How trichomonads manipulate informations from the extracellular medium, transduce such informations, and respond to them by stimulating the activities of some surface molecules and/or releasing enzymes are the aspects concerning trichomonal virulence which are here briefly reviewed and discussed.

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