Stress proteins are immune targets in leprosy and tuberculosis.
AUTOR(ES)
Young, D
RESUMO
To understand the immune response to infection by tuberculosis and leprosy bacilli and to develop improved vaccines, the nature of antigens that are involved in humoral and cell-mediated immunity was investigated. We have determined that five immunodominant protein antigens under study are homologues of stress proteins. This finding and observations with other pathogens suggest that infectious agents may respond to the host environment by producing stress proteins and that these proteins can be important immune targets. We postulate that abundant and highly conserved stress proteins may have "immunoprophylactic" potential for a broad spectrum of human pathogens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=280408Documentos Relacionados
- Identification of macrophage and stress-induced proteins of Mycobacterium tuberculosis.
- Leprosy and the serodiagnostic test for tuberculosis.
- Circulating immune complexes in tuberculosis.
- Guinea pig cellular immune responses to proteins secreted by Mycobacterium tuberculosis.
- Use of serum antibody and lysozyme levels for diagnosis of leprosy and tuberculosis.