Structural Analysis of Chloroquine Resistance Reversal by Imipramine Analogs
AUTOR(ES)
Bhattacharjee, Apurba K.
FONTE
American Society for Microbiology
RESUMO
For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90710Documentos Relacionados
- Nonylphenolethoxylates as Malarial Chloroquine Resistance Reversal Agents
- Reversal of Chloroquine Resistance in Plasmodium falciparum Using Combinations of Chemosensitizers
- Dihydroethanoanthracene Derivatives as In Vitro Malarial Chloroquine Resistance Reversal Agents
- Kinetic analysis in cell culture of the reversal of antiherpes activity of nucleoside analogs by thymidine.
- Polymorphism in Plasmodium falciparum Drug Transporter Proteins and Reversal of In Vitro Chloroquine Resistance by a 9,10-Dihydroethanoanthracene Derivative
