Structural similarities between viroids and transposable genetic elements.
AUTOR(ES)
Kiefer, M C
RESUMO
The primary structures of the tomato planta macho and tomato apical stunt viroids have been determined, and probable secondary structures are proposed. Both viroids can assume the rodlike conformation with extensive base-pairing characteristic of all known viroids. Sequence homologies between the two viroids (75%) and with members of the potato spindle tuber viroid group (73-83%) indicate that they both belong to this group. Comparative sequence analysis of all members of the group reveals striking similarities with the ends of transposable genetic elements. These similarities, the presence of inverted repeats often ending with the dinucleotides U-G and C-A, and flanking imperfect direct repeats suggest that viroids may have originated from transposable elements or retroviral proviruses by deletion of interior portions of the viral (or element) DNA.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=394270Documentos Relacionados
- Multiple pathways of reversion in viroids for conservation of structural elements.
- Inverted repeats of Tn5 are transposable elements.
- Evolution of P transposable elements: sequences of Drosophila nebulosa P elements.
- Developmental expression of Drosophila melanogaster retrovirus-like transposable elements.
- Identification of functional domains and evolution of Tc1-like transposable elements.