Structure and expression of germ line immunoglobulin gamma 2b transcripts.
AUTOR(ES)
Lutzker, S
RESUMO
We have isolated a cDNA copy of a truncated C gamma 2b transcript produced by Abelson murine leukemia virus transformants that spontaneously switch from mu to gamma 2b. The initiation site of this transcript was 2 kilobases 5' to the gamma 2b switch recombination region, demonstrating its germ line origin. Nucleotide sequence analyses suggest that this transcript does not encode a protein. Expression of germ line gamma 2b transcripts in Abelson murine leukemia virus transformants and in normal spleen cells correlated with endogenous gamma 2b class switch activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=363353Documentos Relacionados
- Structure and Expression of Germ Line Immunoglobulin γ2b Transcripts
- Structure and expression of murine germ-line immunoglobulin epsilon heavy chain transcripts induced by interleukin 4.
- Structure of immunoglobulin gamma 2b heavy chain gene cloned from mouse embryo gene library.
- Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma.
- Initiation and processing of two kappa immunoglobulin germ line transcripts in mouse B cells.
