Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter.
AUTOR(ES)
Lazo, P S
RESUMO
We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene. By deletion analysis we have characterized a region upstream of the TATA box which is the promoter region of the gene. Several consensus sequences have been identified, including an SRE and AP-1 binding site whose relative positions are identical to those in the 5' upstream region of the c-fos gene. We have also shown that FosB and c-Fos can downregulate the activity of the fosB promoter to a similar extent. The fosB gene is located in the [A1-B1] region of mouse chromosome 7.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=310376Documentos Relacionados
- Both products of the fosB gene, FosB and its short form, FosB/SF, are transcriptional activators in fibroblasts.
- An alternative spliced form of FosB is a negative regulator of transcriptional activation and transformation by Fos proteins.
- Transcriptional activation and transformation by FosB protein require phosphorylation of the carboxyl-terminal activation domain.
- Fine-structure mapping and complementation analysis of the Escherichia coli cysB gene.
- FosB mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects