Structures of deepoxytrichothecene metabolites from 3'-hydroxy HT-2 toxin and T-2 tetraol in rats.

AUTOR(ES)

Yoshizawa, T

RESUMO

3'-Hydroxy HT-2 toxin and T-2 tetraol, in vivo metabolites of T-2 toxin, were orally administered to Wistar rats, and four metabolites having a trichothec-9,12-diene nucleus, which were termed deepoxytrichothecenes, were newly found in the excreta. Their structures were confirmed as 3'-hydroxy-deepoxy HT-2, 3'-hydroxy-deepoxy T-2 triol, 15-acetyl-deepoxy T-2 tetraol, and deepoxy T-2 tetraol on the basis of mass and nuclear magnetic resonance spectroscopy. Resolution of T-2 metabolites and corresponding deepoxytrichothecenes by gas-liquid and thin-layer chromatography was also described.

Documentos Relacionados

• In vitro formation of 3'-hydroxy T-2 and 3'-hydroxy HT-2 toxins from T-2 toxin by liver homogenates from mice and monkeys.
• Production and characterization of antibodies against HT-2 toxin and T-2 tetraol tetraacetate.
• Assay and Relationship of HT-2 Toxin and T-2 Toxin Formation in Liquid Culture
• In vitro metabolism of T-2 toxin in rats.
• T-2 metabolites in the excreta of broiler chickens administered 3H-labeled T-2 toxin.