Studies on the chemical behavior of 3-(nitroacetyl)-1-ethyl-4-hydroxyquinolin-2(1H)-one towards some electrophilic and nucleophilic reagents

AUTOR(ES)

Ibrahim, Magdy A., Hassanin, Hany M., Gabr, Yassin A., Alnamer, Youssef A.

FONTE

Journal of the Brazilian Chemical Society

DATA DE PUBLICAÇÃO

2012-05

RESUMO

Uma variedade de sistemas heterocíclicos contendo o sistema 1-etilquinolin-2(1H)-ona, foi preparada a partir da reação de 3-(nitroacetil)-1-etil-4-hidroxiquinolin-2(1H)-ona com alguns reagentes eletrofílicos e nucleofílicos. Além da sua ciclização para 5-etil-2-(hidroxiimino)-2,3,4,5-tetrahydrofuro[3,2-c]quinolina-3,4-diona, o composto 3-(nitroacetil)-1-etil-4-hidroxiquinolina-2(1H)-ona foi bromado, clorado, formilado, acetilado, e condensado com cromona-3-carbonitrila e 2-amino-3-formilcromona. Alguns novos pirazolo[4,3-c]quinolina,pirimido [5,4-c]quinolina e derivados de quinolino[4,3-b][1,5]benzodiazepina foram também sintetizados.

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