Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat.

AUTOR(ES)

Firth, G

RESUMO

Reverse phase prepared liposomes of defined composition (dipalmitoyl phosphatidyl choline, cholesterol and dipalmitoyl phosphatidic acid; 7:2:1; DPC) when injected intracerebrally in the rat produced no tissue damage beyond that of the penetrating wound, or altered behaviour pattern over 1 week of observation. The cerebral tissue response and behaviour of rats injected with bleomycin of increasing concentration, free and entrapped within liposomes was studied in short and long term experiments. In separate experiments blood, urine and tissue levels of bleomycin were measured after intracerebral injection of free and liposome entrapped bleomycin in the rat. These studies demonstrated that bleomycin when entrapped within liposomes and injected intracerebrally was of low toxicity to normal cerebral tissue, and was cleared more slowly from the injection site than when the free drug was injected. The results obtained indicated a potential application for drugs entrapped within liposomes acting as a depot preparation in the treatment of cerebral gliomas.

Documentos Relacionados

• A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas.
• Killing of Intraphagocytic Staphylococcus aureus by Dihydrostreptomycin Entrapped Within Liposomes
• Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat.
• Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat.
• Immunohistochemical studies on the localisation and ontogeny of heart fatty acid binding protein in the rat.