Studies on the Synthesis of Vitamin D Analogs with Aromatic D-Ring

AUTOR(ES)

EDUARDO-CANOSA, SILVINA, SIGÜEIRO, MARÍA MARCO, RITA, MOURIÑO, ANTONIO

FONTE

An. Acad. Bras. Ciênc.

DATA DE PUBLICAÇÃO

2018

RESUMO

ABSTRACT Herein, we describe our studies on the synthesis of 1α,25-dihydroxyvitamin D3 analogs possessing a benzene ring replacing the natural 5-membered D-ring by the Wittig-Horner and dienyne approaches. A key feature is the synthesis of a Cr(CO)3-complexed previtamin D derivative that enables the construction of vitamin D analogs with aromatic D-ring through a thermal [1,7]-H sigmatropic shift. This study establishes the basis for the design of new vitamin D analogs containing aromatic D-ring, complexed or uncomplexed to Cr(CO)3 type moieties for specific molecular recognition and drug research and development.

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