Studies on the Toxicity and Antiviral Activity of Various Polynucleotides1
AUTOR(ES)
Black, D. R.
RESUMO
Various polynucleotides were examined for antiviral activity and toxicity in mice. Although the antiviral potency of the various interferon inducers varied, there was a concomitant variation in toxicity. This was reflected by a fivefold range in therapeutic ratio for the various compounds. In addition, no polynucleotide proved to be a more potent interferon inducer than polyinosinic·polycytidylic acid [(poly rI)·(poly rC)]. Our results suggest that there may be intrinsic limitations to the development of polynucleotide interferon inducers having improved therapeutic ratios.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=444387Documentos Relacionados
- In Vitro Studies on the Antiviral Activity of 1,3-Bis(2-Chloroethyl)-1-Nitrosourea
- Cell Culture Studies on the Antiviral Activity of Ether Derivatives of 5-Hydroxymethyldeoxyuridine
- Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic of 2-methylthioinosinic acid.
- STUDIES ON THE CHRONIC TOXICITY OF CHLOROQUINE (SN-7618) 1
- Preclinical evaluation of antiviral activity and toxicity of Abbott A77003, an inhibitor of the human immunodeficiency virus type 1 protease.