Study of microvascular thrombosis in lung biopsies of patients with Wegeners granulomatosis / Estudo da trombose microvascular em biópsias pulmonares de pacientes com granulomatose de Wegener

AUTOR(ES)

Alfredo Nicodemos da Cruz Santana

DATA DE PUBLICAÇÃO

2008

RESUMO

Wegeners granulomatosis (GW) is associated with thromboembolic events. In this work, we quantified the thrombus in small/medium-sized pulmonary arteries of patients with GW (n:24) compared to normal controls (n:16). The results showed that the GW and control arteries were similar regarding total area. The thrombus area was significantly increased in GW compared to controls; in contrast, the free lumen area was significantly decreased in GW compared to controls. In summary, this study shows obstruction of microvascular bed in GW, suggesting a possible role of thrombosis in situ in pathophysiology of this vasculitis

ASSUNTO(S)

antibodies antineutrophil cytoplasmic pulmão granulomatose de wegener vasculitis thrombosis vasculite trombose lung biópsia wegener granulomatosis anticorpos anticitoplasma de neutrófilos biopsy

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