Study of the expression of Mdm2, P53, P21, and AKT proteins in benign neoplasms from salivary gland / Estudo da expressão das proteínas MDM2, P53, P21WAF1 e AKT em neoplasias benignas de glândula salivar

AUTOR(ES)

Yonara Maria Freire Soares Marques

DATA DE PUBLICAÇÃO

2006

RESUMO

The P53 protein can be altered in virtually all human cancers and in the absence of mutations, P53 inactivation is possible via complex formation with others proteins, such as the Mdm2. Previous studies from our laboratory showed overexpression of mdm2 and lack of p53 expression in pleomorphic adenomas. The aim of this study was to analyze the expression of Mdm2, P53, P21 and Akt proteins in pleomorphic adenomas and myoepiteliomas by Western blotting, immunohistochemistry and immunofluorescence techniques. Overexpression of Mdm2 and Akt was present in the majority of cell lineages and tumors studied, while the expression of P53 and P21 proteins was considered absent. Overexpression of Mdm2 and Akt are related to the tumorigenesis of benign salivary gland neoplasms.

ASSUNTO(S)

p53 akt p21 mioepitelioma p53 myoepithelioma adenoma pleomórfico mdm2 akt mdm2 p21waf1 pleomorphic adenoma

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