Subacute administration of a TRH analogue (RX77368) in motorneuron disease: an open study.

AUTOR(ES)

Modarres-Sadeghi, H

RESUMO

Sixteen patients with motor neuron disease received RX77368, a TRH analogue, IV, repeatedly over 1-12 weeks (median 2 weeks). Slight to moderate improvement in bulbar function, particularly speech, was reproduced or persisted with repeated infusions in 8 of 12 responders over a median of 18 days (range 14-90) during the period of study. Cramps (5/9) and spasticity (5/8) improved for a median of 14 days (range 7-35) and 7 days (range 2-14) respectively. The highest benefit/side effect ratio was seen with 0.2 mg/kg (0.15 mg/kg in those with severe bulbar palsy) every 3-4 days. Long term studies with this analogue in MND are indicated.

Documentos Relacionados

• Comparative efficacy and safety of intravenous and oral administration of a TRH analogue (RX77368) in motor neuron disease.
• Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease.
• Continuous response variable trial design in motor neuron disease: long term treatment with a TRH analogue (RX77368).
• The effects of repeated administration of a long acting TRH analogue (RX77368), on TSH, T4, T3 and prolactin in patients with motor neuron disease.
• Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).