Subtraction by addition: domesticated transposases in programmed DNA elimination
AUTOR(ES)
Motl, Jason A.
FONTE
Cold Spring Harbor Laboratory Press
RESUMO
The ciliate Paramecium tetraurelia must eliminate ∼60,000 short sequences from its genome to generate uninterrupted coding sequences in its somatic macronucleus. In this issue of Genes & Development, Baudry and colleagues (pp. 2478–2483) identify the protein that excises these noncoding sequences: a domesticated piggyBac transposase that has been adapted to remove what are likely the remnants of transposon insertions. This new study reveals how addition of a transposase to small RNA-directed silencing machinery can guide major genome reorganization.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2779744Documentos Relacionados
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