Successful Trovafloxacin Prophylaxis against Experimental Streptococcal Aortic Valve Endocarditis
AUTOR(ES)
Katsarolis, Ioannis
FONTE
American Society for Microbiology
RESUMO
Single-dose trovafloxacin (15 mg/kg given intravenously [i.v.]) and ampicillin (40 mg/kg given i.v.) protected 38 and 33% of animals challenged with an ampicillin-tolerant strain of Streptococcus oralis, respectively. As a double-dose regimen, trovafloxacin afforded total protection (100%; P < 0.001 versus controls). Trovafloxacin is the first fluoroquinolone effective in preventing experimental streptococcal endocarditis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90109Documentos Relacionados
- Successful single-dose teicoplanin prophylaxis against experimental streptococcal, enterococcal, and staphylococcal aortic valve endocarditis.
- Single-Oral-Dose Azithromycin Prophylaxis against Experimental Streptococcal or Staphylococcal Aortic Valve Endocarditis
- Efficacy of Trovafloxacin against Experimental Staphylococcus aureus Endocarditis
- Efficacy of Trovafloxacin in Treatment of Experimental Staphylococcal or Streptococcal Endocarditis
- Chemotherapy of experimental streptococcal endocarditis. IV. Further observations on prophylaxis.