Suppressive effect on polyclonal B-cell activation of a synthetic peptide homologous to a transmembrane component of oncogenic retroviruses.
AUTOR(ES)
Mitani, M
RESUMO
Purified feline leukemia virus, UV light-inactivated feline leukemia virus, and a synthetic peptide (CKS-17) homologous to a well-conserved region of the transmembrane components of several human and animal retroviruses were each studied for their effects on IgG production by feline peripheral blood lymphocytes. Using a reverse hemolytic plaque assay, both the viable virus and the UV-inactivated feline leukemia virus, but not the CKS-17, activated B lymphocytes to secrete IgG. When staphylococcal protein A, a polyclonal B-cell activator, was used to stimulate IgG synthesis by feline lymphocytes, the viable virus, the UV-inactivated virus, and the CKS-17 peptide each strongly suppressed IgG secretion without compromising viability of the lymphocytes. These findings suggest that the immunosuppressive influences of feline leukemia virus on immunoglobulin synthesis may reside in a conserved portion of the envelope glycoprotein that includes the region homologous to CKS-17.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=304178Documentos Relacionados
- Single cell studies on the role of B-cell stimulatory factor 1 in B-cell activation.
- The VP7 Outer Capsid Protein of Rotavirus Induces Polyclonal B-Cell Activation
- Identification of a Polyclonal B-Cell Activator in Plasmodium falciparum
- Evidence for autoantibody production associated with polyclonal B-cell activation by Pseudomonas aeruginosa.
- Polyclonal B-cell activation induced by extracts of Gram-negative bacteria isolated from periodontally diseased sites.