SURVEY AND SUMMARY: ADEPTs: information necessary for subcellular distribution of eukaryotic sorting isozymes resides in domains missing from eubacterial and archaeal counterparts

AUTOR(ES)

Stanford, David R.

FONTE

Oxford University Press

RESUMO

Sorting isozymes are encoded by single genes, but the encoded proteins are distributed to multiple subcellular compartments. We surveyed the predicted protein sequences of several nucleic acid interacting sorting isozymes from the eukaryotic taxonomic domain and compared them with their homologs in the archaeal and eubacterial domains. Here, we summarize the data showing that the eukaryotic sorting isozymes often possess sequences not present in the archaeal and eubacterial counterparts and that the additional sequences can act to target the eukaryotic proteins to their appropriate subcellular locations. Therefore, we have named these protein domains ADEPTs (Additional Domains for Eukaryotic Protein Targeting). Identification of additional domains by phylogenetic comparisons should be generally useful for locating candidate sequences important for subcellular distribution of eukaryotic proteins.

Documentos Relacionados

• SURVEY AND SUMMARY: Novel domains and orthologues of eukaryotic transcription elongation factors
• SURVEY AND SUMMARY: The phylogenetic distribution of bacterial ribonucleases
• SURVEY AND SUMMARY: Structural classification of zinc fingers
• SURVEY AND SUMMARY: The pre-ribosomal network
• SURVEY AND SUMMARY: Comparative analysis of editosome proteins in trypanosomatids