Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England
AUTOR(ES)
Christophers, Jacqueline
FONTE
American Society for Microbiology
RESUMO
Acyclovir (ACV) has been used for more than 15 years in the management of herpes simplex virus (HSV) and varicella-zoster virus (VZV) disease. The present survey was undertaken to assess the level of ACV resistance in the population. More than 2,000 HSV isolates from both immunocompetent and immunocompromised patients in northwest England were collected over a 2-year period and tested for sensitivity to ACV. These studies suggested a prevalence of resistance of approximately 0.1 to 0.6% in immunocompetent individuals, with no apparent difference in prevalence between treated and untreated groups. In line with previous studies, the prevalence of resistance in treated immunocompromised individuals was approximately 6%.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105557Documentos Relacionados
- Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.
- Development of Clinical Resistance to Acyclovir in Herpes Simplex Virus-Infected Mice Receiving Oral Therapy
- Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy.
- Cooperative effects between two acyclovir resistance loci in herpes simplex virus.
- Herpes Simplex Virus Resistance to Acyclovir and Penciclovir after Two Decades of Antiviral Therapy