Susceptibilities of oxyR regulon mutants of Escherichia coli and Salmonella typhimurium to isoniazid.
AUTOR(ES)
Rosner, J L
RESUMO
Escherichia coli and Salmonella typhimurium are normally resistant to > 500 micrograms of the antituberculosis drug isonicotinic acid hydrazide (isoniazid; INH) per ml. Susceptibility to INH (< 50 micrograms/ml) has now been found for mutants that are deficient in OxyR, the oxidative stress response regulator. Two OxyR-regulated enzymes, alkyl hydroperoxide reductase and hydroperoxidase I, were identified as playing important roles in INH resistance. OxyR regulon mutants should be useful for identifying other determinants of INH resistance in both E. coli and Mycobacterium tuberculosis and for finding new INH-like drugs.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=192262Documentos Relacionados
- Comparison of the sensitivities of Salmonella typhimurium oxyR and katG mutants to killing by human neutrophils.
- In Vivo Transcription of the Escherichia coli oxyR Regulon as a Function of Growth Phase and in Response to Oxidative Stress
- Effects of peroxides on susceptibilities of Escherichia coli and Mycobacterium smegmatis to isoniazid.
- Identification and characterization of hydrogen peroxide-sensitive mutants of Escherichia coli: genes that require OxyR for expression.
- Computation-Directed Identification of OxyR DNA Binding Sites in Escherichia coli