Susceptibility of Neisseria gonorrhoeae to protegrins.
AUTOR(ES)
Qu, X D
RESUMO
We developed a sensitive and quantitative radial diffusion method to ascertain the susceptibility of six strains of Neisseria gonorrhoeae to antimicrobial peptides derived from mammalian leukocytes. The test organisms included the well-characterized serum-resistant FA19 and serum-sensitive F62 strains plus four antibiotic-resistant clinical isolates. Although each N. gonorrhoeae strain was resistant to human neutrophil defensins, all six were exquisitely sensitive to protegrins, a family of small beta-sheet antimicrobial peptides recently identified in porcine leukocytes. Protegrin-treated N. gonorrhoeae became vacuolated and had striking membrane changes when viewed by transmission and scanning electron microscopy. Because low concentrations of protegrins can also inactivate Chlamydia trachomatis and human immunodeficiency virus, they show promise for development as topical agents to avert sexually transmitted diseases.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=173910Documentos Relacionados
- Susceptibility of Neisseria gonorrhoeae to cefotaxime and ceftizoxime.
- Susceptibility of Neisseria meningitidis and Neisseria gonorrhoeae isolates to N-formimidoyl thienamycin.
- Susceptibility of Chlamydia trachomatis to protegrins and defensins.
- Possible Mechanism of Decreased Susceptibility of Neisseria gonorrhoeae to Penicillin
- In vitro susceptibility of Neisseria gonorrhoeae to 2-acetylpyridine thiosemicarbazones.
