Synergistic Lethal Effect of a Combination of Phage Lytic Enzymes with Different Activities on Penicillin-Sensitive and -Resistant Streptococcus pneumoniae Strains

AUTOR(ES)

Loeffler, J. M.

FONTE

American Society for Microbiology

RESUMO

Pal and Cpl-1, two purified bacteriophage lytic enzymes, were tested for their in vitro activity, alone and in combination, against several serotypes of Streptococcus pneumoniae, including penicillin-resistant strains. The enzymes demonstrated synergism in their ability to cleave the bacterial peptidoglycan and thus may be more efficient for the prevention and elimination of pneumococcal colonization.

Documentos Relacionados

• Cell Envelope of Neisseria gonorrhoeae: Outer Membrane and Peptidoglycan Composition of Penicillin-Sensitive and -Resistant Strains
• Activities of Ertapenem, a New Long-Acting Carbapenem, against Penicillin-Sensitive or -Resistant Pneumococci in Experimental Meningitis
• Interaction of penicillin with the bacterial cell: penicillin-binding proteins and penicillin-sensitive enzymes.
• Genetic relationships of penicillin-susceptible and -resistant Streptococcus pneumoniae strains isolated on different continents.
• Penicillin-binding components of penicillin-susceptible and -resistant strains of Streptococcus pneumoniae.