Synergy Tests by E Test and Checkerboard Methods of Antimicrobial Combinations against Brucella melitensis

AUTOR(ES)

Orhan, Gani

FONTE

American Society for Microbiology

RESUMO

Two different synergy testing methods, the checkerboard and the E test methods, were used to compare the in vitro efficacies of various antimicrobial combinations against 16 Brucella melitensis strains isolated from blood cultures. The rate of agreement of the E test and checkerboard methods was found to be 55%. The most concordant results were found for the streptomycin-doxycycline combination in 12 (75%) tests, in which four strains showed synergistic activity by E test and antagonistic activity by the checkerboard method and in which one strain showed antagonistic activity by both methods. Even though each of these methods uses different conditions and endpoints, the results of both methods frequently agreed.

Documentos Relacionados

• Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test.
• Comparative in vitro activities of ofloxacin, difloxacin, ciprofloxacin, and other selected antimicrobial agents against Brucella melitensis.
• Comparison of E Test to Microdilution for Determining In Vitro Activities of Antibiotics against Brucella melitensis
• Evaluation of allergic and serological tests for diagnosing Brucella melitensis infection in sheep.
• Evaluation of serological tests for diagnosis of Brucella melitensis infection of goats.