Synthesis and antimicrobial activity of a series of caespitin derivatives.
AUTOR(ES)
Van der Schyf, C J
RESUMO
Chemical modification of the naturally occurring phlorophenone antimicrobial agent caespitin is described. These modifications include variations in the phenone side chain, substitution with prenyl, allyl, and benzyl in the 4-position of the phlorophenone nucleus, and ring cyclizations via etherification to give furan and chroman compounds. Several of these derivatives show enhanced in vitro potency over caespitin. Studies on the development of microbial resistance against these compounds show that no or very little resistance developed after several passes of these compounds in representative microbial strains.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180563Documentos Relacionados
- Synthesis and antimicrobial activity of amphiphilic carbohydrate derivatives
- In vitro activity and in vivo efficacy of a new series of 9-deoxo-12-deoxy-9,12-epoxyerythromycin A derivatives.
- Auxin Activity of Some Indole Derivatives. 12
- Synthesis and binding properties of conjugates between oligodeoxynucleotides and daunorubicin derivatives.
- Inhibition of metallo-beta-lactamases by a series of mercaptoacetic acid thiol ester derivatives.
