Synthesis and Biological Evaluation of Benzo[f]indole-4,9-diones N-Linked to Carbohydrate Chains as New Type of Antitumor Agents
AUTOR(ES)
Dias, Flaviana R. F.; Guerra, Fabiana S.; Lima, Fernanda A.; Castro, Yasmin K. C. de; Ferreira, Vitor F.; Campos, Vinícius R.; Fernandes, Patrícia D.; Cunha, Anna C.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2021-03
RESUMO
In this work, we report the synthesis of three series of carbohydrate-based benzo[f]indole-4,9-diones and amino-1,4-naphthoquinone derivatives and evaluated their cytotoxic activity against eight human cancer cell lines. Several compounds showed a promising cytotoxic activity toward the tumor cell lines (half maximal inhibitory concentration (IC50) < 10.0 μM). The importance of the substitution pattern of the quinone derivatives on the antitumor activity was also discussed. 3-Carboethoxy-2-methyl-benzo[f]indole-4,9-dione derivatives were more cytotoxic than their parent compounds and amino-1,4-naphthoquinones. Unlike clinically useful anticancer agent doxorubicin, the majority of synthesized compounds did not exhibit any lytic effects against erythrocytes or normal human leukocytes.
Documentos Relacionados
- N-Linked Glycan Chains on S-Allele-Associated Glycoproteins from Nicotiana alata.
- Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential.
- Glycosylation site-binding protein is not required for N-linked glycoprotein synthesis.
- Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation.
- The Rate of Phaseolin Assembly Is Controlled by the Glucosylation State of Its N-Linked Oligosaccharide Chains.