Synthesis and characterization of new amino acyl-4-thiazolidones

AUTOR(ES)

Leite, Ana Cristina Lima, Santos, Luciene Maria F., Moreira, Diogo Rodrigo de M., Brondani, Dalci José

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2007-04

RESUMO

A series of heterocyclic compounds with a 4-thiazolidone nucleus and amino acyl moiety were synthesized by protection reaction of thiosemicarbazide using the symmetrical anhydride (Boc)2O and cyclization with chloroacetic acid under mild conditions. Trifluoroacetic acid was used to obtain 4-thiazolidone and the alpha-amino acid condensation reactions were carried out using strategies for peptide synthesis. The characterization of this new class of compounds was performed using IR and ¹H-NMR spectroscopy.

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