Synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides: evaluation of antioxidant and antimicrobial activities

AUTOR(ES)

Sarmiento-Sánchez, Juan I., Montes-Avila, Julio, Ochoa-Terán, Adrián, Delgado-Vargas, Francisco, Wilson-Corral, Victor, Díaz-Camacho, Sylvia P., García-Páez, Fernando, Bastidas-Bastidas, Pedro

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2014

RESUMO

A facile one-step synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides and TMSA was described. This paper determines their antimicrobial activity against nine human bacterial pathogens by the broth microdilution method; antioxidant activity by DPPH• inactivation and a ferric-reducing power assay; and toxicity by a brine shrimp, Artemia salina, assay. The 1H-benzoxazine-2,4-dione yields were in the range of 57 to 98%. The novel compound 1H-pyrazino[2,3-][1,3]oxazine-2,4-dione 4c showed the highest antioxidant capacity (DPPH 35.4% and FRAP 0.063 µmol TEs/µmol).

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