Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(pyridin-3-yl)-1H-benzimidazole as new Delavirdine analogues
AUTOR(ES)
Pessoa-Mahana, David, Núñez, Andrés, Espinosa, Christian, Mella-Raipán, Jaime, Pessoa-Mahana, Hernán
FONTE
Journal of the Brazilian Chemical Society
DATA DE PUBLICAÇÃO
2010
RESUMO
A síntese de uma série de arilpiperazinas ligadas à estrutura 2-(piridina-3-il)-1H-benzo[d]imidazol, através de um linker alquílico é relatada. Os novos derivados 1-(2-(4-arilpiperazina-1-il)alquil)-2-(piridina-3-il)-1H-benzimidazol são estruturalmente relacionados à droga anti-HIV-1 Delavirdina e pertencem à família bis(heteroaril)piperazinas (BHAPs), um conhecido grupo de inibidores da transcriptase reversa HIV-1.
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