Synthesis of platinum complexes from N-benzyl ethylenediamine derivatives

AUTOR(ES)

Almeida, Mauro V. de, Cesar, Eloi T., Felício, Emanoel de C. A., Fontes, Ana Paula S., Robert-Gero, Malka

FONTE

Journal of the Brazilian Chemical Society

DATA DE PUBLICAÇÃO

2000-04

RESUMO

O ligante N-benziletilenodiamina e derivados foram preparados em bons rendimentos utilizando-se metodologia diferente da descrita na literatura. Espectros de RMN de ¹H e de 13C foram empregados para a caracterização destes compostos. Nove novos complexos de platina(II) com estes ligantes, análogos da cisplatina e da carboplatina, foram preparados e caracterizados. Testes preliminares in vitro em linhagens celulares de carcinoma bucal humano (células KB) indicam que estes complexos são citotóxicos.

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