Synthetic progestogen-oestrogen therapy and uterine changes

AUTOR(ES)

Azzopardi, J. G.

RESUMO

Continuous therapy with synthetic progestogen-oestrogen produces marked atrophy of endometrial glands and massive pseudodecidual stromal transformation. Cyclical therapy produces initially a `frustrated secretory response' with precocious attempts at secretion in poorly developed glands. Pseudodecidua appears about the 20th day. With later cycles there is progressively greater gland atrophy while pseudodecidua is less marked. A possible inductive role of the glands on the stromal response to progestogens is postulated. The effect of different drugs and dosages is discussed.

Documentos Relacionados

• Effect on endometrium of long term treatment with continuous combined oestrogen-progestogen replacement therapy: follow up study
• Effects of oestrogen and progestogen on serum levels of α2-macroglobulin, transferrin, albumin, and IgG
• Synthetic progestagen-oestrogen preparations and endometrial morphology
• Estrogen monotherapy and combined estrogen-progestogen replacement therapy attenuate aortic accumulation of cholesterol in ovariectomized cholesterol-fed rabbits.
• Atypical epithelial changes in the uterine cervix