T-cell cytokine responses in human infection with Mycobacterium tuberculosis.
AUTOR(ES)
Zhang, M
RESUMO
Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=173444Documentos Relacionados
- Human T-cell responses to secreted antigen fractions of Mycobacterium tuberculosis.
- T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis.
- T-Cell Responses to CD1-Presented Lipid Antigens in Humans with Mycobacterium tuberculosis Infection
- Evolution of CD4 T-cell subsets following infection of naive and memory immune mice with Mycobacterium tuberculosis.
- In vivo and in vitro characterization of murine T-cell clones reactive to Mycobacterium tuberculosis.
