T-Cell Lymphoma Caused by Herpesvirus Saimiri C488 Independently of ie14/vsag, a Viral Gene with Superantigen Homology

AUTOR(ES)

Knappe, Andrea

FONTE

American Society for Microbiology

RESUMO

The immediate-early gene ie14/vsag of herpesvirus saimiri has homology with murine superantigens. We compared the pathogenesis of infection with either ie14/vsag deletion mutants or wild-type virus C488 in cottontop tamarin monkeys (Saguinus oedipus). Two weeks after infection, all animals developed acute T-cell lymphomas independently of the presence of the viral ie14/vsag gene.

Documentos Relacionados

• The superantigen-homologous viral immediate-early gene ie14/vsag in herpesvirus saimiri-transformed human T cells.
• Immortalization of human T cells expressing T-cell receptor gamma delta by herpesvirus saimiri.
• Familial T‐cell non‐Hodgkin lymphoma caused by biallelic MSH2 mutations
• Selectable recombinant herpesvirus saimiri is capable of persisting in a human T-cell line.
• ORF73 of Herpesvirus Saimiri Strain C488 Tethers the Viral Genome to Metaphase Chromosomes and Binds to cis-Acting DNA Sequences in the Terminal Repeats