Task-Dependent Modulation of Primary Afferent Depolarization in Cervical Spinal Cord of Monkeys Performing an Instructed Delay Task
AUTOR(ES)
Seki, Kazuhiko
FONTE
American Physiological Society
RESUMO
Task-dependent modulation of primary afferent depolarization (PAD) was studied in the cervical spinal cord of two monkeys performing a wrist flexion and extension task with an instructed delay period. We implanted two nerve cuff electrodes on proximal and distal parts of the superficial radial nerve (SR) and a recording chamber over a hemi-laminectomy in the lower cervical vertebrae. Antidromic volleys (ADVs) in the SR were evoked by intraspinal microstimuli (ISMS, 3–10 Hz, 3–30 μA) applied through a tungsten microelectrode, and the area of each ADV was measured. In total, 434 ADVs were evoked by ISMS in two monkeys, with onset latency consistently shorter in the proximal than distal cuffs. Estimated conduction velocity suggest that most ADVs were caused by action potentials in cutaneous fibers originating from low-threshold tactile receptors. Modulation of the size of ADVs as a function of the task was examined in 281 ADVs induced by ISMS applied at 78 different intraspinal sites. The ADVs were significantly facilitated during active movement in both flexion and extension (P < 0.05), suggesting an epoch-dependent modulation of PAD. This facilitation started 400–900 ms before the onset of EMG activity. Such pre-EMG modulation is hard to explain by movement-induced reafference and probably is associated with descending motor commands.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2712276Documentos Relacionados
- Coherent oscillations in monkey motor cortex and hand muscle EMG show task-dependent modulation.
- Task-dependent influences of attention on the activation of human primary visual cortex
- Task-dependent changes in the responses to low-threshold cutaneous afferent volleys in the human lower limb.
- Task-Dependent Role for Dorsal Striatum Metabotropic Glutamate Receptors in Memory
- Task-dependent changes in the response of human wrist joints to mechanical disturbance.