Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats
AUTOR(ES)
Zijlmans, J. Mark J. M.
FONTE
The National Academy of Sciences of the USA
RESUMO
The ultra-long telomeres that have been observed in mice are not in accordance with the concept that critical telomere shortening is related to aging and immortalization. Here, we have used quantitative fluorescence in situ hybridization to estimate (T2AG3)n lengths of individual telomeres in various mouse strains. Telomere lengths were very heterogeneous, but specific chromosomes of bone marrow cells and skin fibroblasts from individual mice had similar telomere lengths. We estimate that the shortest telomeres are around 10 kb in length, indicating that each mouse cell has a few telomeres with (T2AG3)n lengths within the range of human telomeres. These short telomeres may be critical in limiting the replicative potential of murine cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=23837Documentos Relacionados
- Inter-chromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development
- Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination
- Variations in the Number of the Y Chromosomal Rrna Genes in DROSOPHILA HYDEI
- Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutions
- Wild-derived inbred mouse strains have short telomeres