Temperature Adaptation of Enzymes: Roles of the Free Energy, the Enthalpy, and the Entropy of Activation

AUTOR(ES)

Low, Philip S.

RESUMO

The enzymic reactions of ectothermic (cold-blooded) species differ from those of avian and mammalian species in terms of the magnitudes of the three thermodynamic activation parameters, the free energy of activation (ΔG⧧), the enthalpy of activation (ΔH⧧), and the entropy of activation (ΔS⧧). Ectothermic enzymes are more efficient than the homologous enzymes of birds and mammals in reducing the ΔG⧧ “energy barrier” to a chemical reaction. Moreover, the relative importance of the enthalpic and entropic contributions to ΔG⧧ differs between these two broad classes of organisms.

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