Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination.
AUTOR(ES)
Haspel, M V
RESUMO
Mutagenesis of mouse hepatitis virus with 5-azacytidine or 5-fluorouracil yielded several temperature-sensitive mutants. Mutants have been isolated that dramatically enhance the production of demyelinating disease over that previously noted with the wild-type virus. This reproducible model should now make possible the precise elucidation of the pathogenic mechanism and molecular basis of this virus-induced demyelination.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=392925Documentos Relacionados
- Map locations of mouse hepatitis virus temperature-sensitive mutants: confirmation of variable rates of recombination.
- Temperature-sensitive mutants of Japanese encephalitis virus.
- Temperature-sensitive Mutants of Respiratory Syncytial Virus
- Characterization of temperature-sensitive mutants of Pichinde virus.
- Biochemical characterization of temperature-sensitive rabies virus mutants.
