Temperature-Sensitive Mutation in Regulation of Ribonucleic Acid Synthesis in Escherichia coli

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RESUMO

An Escherichia coli mutant dependent on exogenous transfer ribonucleic acid (RNA) for bulk RNA formation at 42 C has been isolated, starting from a parental strain permeable to RNA. In the absence of added transfer RNA at the high temperature, protein synthesis stopped, and the strain formed little if any ribosomal RNA.

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