Temporal binding via cortical coincidence detection of specific and nonspecific thalamocortical inputs: A voltage-dependent dye-imaging study in mouse brain slices

AUTOR(ES)

Llinás, Rodolfo R.

FONTE

The National Academy of Sciences

RESUMO

Voltage-sensitive dye imaging of mouse thalamocortical slices demonstrated that electrical stimulation of the centrolateral intralaminar thalamic nucleus (CL) resulted in the specific activation of thalamic reticular nucleus, striatum/putamen, and cortical layers 5, 6, and 1. By contrast, ventrobasal (VB) thalamic stimulation, while activating the reticular and basal ganglia nuclei, also activated directly layers 4 and deep 5 of the cortex. Conjoined stimulation of the VB and CL nuclei resulted in supralinear summation of the two inputs at cortical output layer 5, demonstrating coincidence detection along the apical dendrites. This supralinear summation was also noticed at gamma band stimulus frequency (≈40 Hz). Direct stimulation of cortical layer 1, after a radial section of the cortex that spared only that layer, was shown to sum supralinearly with the cortical activation triggered by VB stimulation, providing a second demonstration for coincidence detection. Coincidence detection by coactivation of the specific (VB) and nonspecific (CL) thalamic nuclei has been proposed as the basis for the temporal conjunction that supports cognitive binding in the brain.

Documentos Relacionados

• Voltage-dependent dye coupling at a rectifying electrotonic synapse of the crayfish.
• Voltage-dependent potassium channels in mouse Schwann cells.
• Voltage-dependent inactivation of a calcium channel.
• Dynorphin A decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones.
• Voltage-dependent block by zinc of single calcium channels in mouse myotubes.