THE ACRASIN ACTIVITY OF 3′,5′-CYCLIC NUCLEOTIDES

AUTOR(ES)

Chassy, Bruce M.

RESUMO

3′,5′-Cyclic nucleotides are acrasins for the cellular slime mold, Dictyostelium discoideum; they have chemotactic activity on the myxamoebae at very low concentrations. However, not all cyclic nucleotides can evoke the adhesiveness necessary for aggregate formation. 2′,3′-Cyclic nucleotides and dibutyrylcyclic adenosine monophosphate are not acrasins, though they enhance the rate of differentiation and morphogenesis. The addition of 3′,5′-cyclic nucleotides to agar test plates stimulates the rate of morphogenesis. While the stimulatory effect of cyclic nucleotides is concentration-dependent, it is fairly uniform between pH 5 and 7, with an optimum at pH 6. The acrasins may be metabolized by extracellular phosphodiesterase to 5′-nucelotides which may then stimulate differentiation and morphogenesis.

Documentos Relacionados

• The acrasin activity of adenosine-3',5'-cyclic phosphate.
• Renal effects of adenosine 3′,5′-cyclic monophosphate and dibutyryl adenosine 3′,5′-cyclic monophosphate: Evidence for a role for adenosine 3′,5′-cyclic monophosphate in the regulation of proximal tubular sodium reabsorption
• RADIOIMMUNOASSAY FOR THE MEASUREMENT OF ADENOSINE 3′,5′-CYCLIC PHOSPHATE*
• Adenosine 3',5'-cyclic monophosphate in Vibrio cholerae.
• Absolute configuration of Rp-uridine 3',5'-cyclic phosphorothioate.